Candida biproducts research
Posted 08-21-2008 at 10:51 AM by bunnyday
As you may know, I'm not onboard the anti-candida program per se but I do want to understand what is up with it.
"Since, as shown here in vitro, production of neutrophil chemotaxins by C. albicans is independent of glucose-feeding, a possible role of Candida-chemotaxins in the pathophysiology of cutaneous candidosis can no longer be excluded."
I believe this translates into the idea that Candida biproducts of its growth include things (chemotaxins) that are active active against neutrophils (especially an abundant type of granular white blood cell that is highly destructive of microorganisms)! This research would indicate that candida can do this regardless of sugar (glucose) being there or not in the cutaneous (skin?) layers. food for thought...
Acta Derm Venereol. 1992;72(1):1-3.Links
Candida albicans grown in glucose-free media contains serum-independent chemotactic activity.
Brasch J, Schröder JM, Christophers E.
Department of Dermatology, University of Kiel, Germany.
Infection of skin with Candida albicans is usually followed by infiltration of neutrophil granulocytes (PMN). So far, chemotaxins for PMN have been isolated from C. albicans cultures grown in the presence of glucose. However, since glucose is not present in skin in vivo, a contribution of such factors to Candida-triggered cutaneous inflammation would appear unlikely. In order to clarify this question, chemotactic activity was measured in extracts from three different strains of C. albicans which were grown in five different peptone media free of carbohydrates and serum. In addition, four culture systems were supplemented with lipids normally present in human stratum corneum, including a triglyceride, cholesterol, and sphingomyelin. In all sugar-free grown cultures, serum-independent chemotactic activity was detected by use of the Boyden chamber technique. Since, as shown here in vitro, production of neutrophil chemotaxins by C. albicans is independent of glucose-feeding, a possible role of Candida-chemotaxins in the pathophysiology of cutaneous candidosis can no longer be excluded.
"Since, as shown here in vitro, production of neutrophil chemotaxins by C. albicans is independent of glucose-feeding, a possible role of Candida-chemotaxins in the pathophysiology of cutaneous candidosis can no longer be excluded."
I believe this translates into the idea that Candida biproducts of its growth include things (chemotaxins) that are active active against neutrophils (especially an abundant type of granular white blood cell that is highly destructive of microorganisms)! This research would indicate that candida can do this regardless of sugar (glucose) being there or not in the cutaneous (skin?) layers. food for thought...
Acta Derm Venereol. 1992;72(1):1-3.Links
Candida albicans grown in glucose-free media contains serum-independent chemotactic activity.
Brasch J, Schröder JM, Christophers E.
Department of Dermatology, University of Kiel, Germany.
Infection of skin with Candida albicans is usually followed by infiltration of neutrophil granulocytes (PMN). So far, chemotaxins for PMN have been isolated from C. albicans cultures grown in the presence of glucose. However, since glucose is not present in skin in vivo, a contribution of such factors to Candida-triggered cutaneous inflammation would appear unlikely. In order to clarify this question, chemotactic activity was measured in extracts from three different strains of C. albicans which were grown in five different peptone media free of carbohydrates and serum. In addition, four culture systems were supplemented with lipids normally present in human stratum corneum, including a triglyceride, cholesterol, and sphingomyelin. In all sugar-free grown cultures, serum-independent chemotactic activity was detected by use of the Boyden chamber technique. Since, as shown here in vitro, production of neutrophil chemotaxins by C. albicans is independent of glucose-feeding, a possible role of Candida-chemotaxins in the pathophysiology of cutaneous candidosis can no longer be excluded.
Recent Blog Entries by bunnyday
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- Gut Flora Help Regulate Appetite?!?!?!?! (08-21-2008)
- Candida albicans allergens reactive with specific IgE in asthma and atopic eczema patients. (08-21-2008)
- Candida biproducts research (08-21-2008)
