Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

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    Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    A study looking at IL-15 (interleukin-15, an inflammatory protein that humans produce) which is already implicated as an aggravator of inflammatory diseases is now implicated in celiac disease. Additionally in the study, they found that retinoic acid acts as a stimulator or something of IL-15. Stimulation of IL-15 will trigger or worsen underlying auto-immune or inflammatory disease...

    "An interesting side-note: the study also found that retinoic acid, a vitamin-A derivative found in acne treatments such as Retin-A and Accutane, may be another culprit in celiac disease. That’s because retinoic acid acts as IL-15′s little sidekick, fueling the production of the protein and further exacerbating celiac symptoms."

    Big News for Celiac Treatment Comes in a Small Package

    So if you used Accutane or Retin-A and found your KP got worse, look into underlying auto-immune or inflammatory disease. (While the link I posted is celiac-centric, since IL-15 is an aggravator of rheumatoid arthritis and other inflammatory diseases, stimulation of IL-15 might cause RA symptoms or celiac symptoms or other such diseases - sarcoidosis, chronic hepatitis C, and ulcerative colitis, to name a few.)
    Last edited by bunnyday; 02-24-2011 at 12:22 PM.
    - bd: 46 yo F; Dr. Woods Black Soap w/Shea Butter for facewash; Sea Salt + Epsom Salt scrub in shower; Cetaphil RestoraDerm unscented lotion, Alba Botanica Kona Coffee After-Sun lotion on face; reg. exercise; OilPulling; a basic multi-vite plus calcium/Vit D, o3s; eating GLUTEN-FREE DIET for Celiac Disease, and not much dairy as I get allergic reaction; Arms 99% clear, face neck chest 98%, legs 90% clear, butt is 99% clear. All dietary treatments above help reduce my sinus congestion and joint pain besides help my skin.

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    I used accutane for 5 days, because of side effects I couldn't continue. Instead I'm using retin-A cream. It's been a week. It also shows very similar symptoms to accutane. My lips are still very dry and there are cracks. I have hair loss. I made a quick search on the internet, many people say it increases hairloss if used in excess amounts. I don't know what to do. My skin or my hair? KP is 100% an auto-immune or inflammatory disease. The problem is to find what causes inflammation or auto-immune response.
    Last edited by levant; 02-24-2011 at 04:42 PM.

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    Quote Originally Posted by levant View Post
    I used accutane for 5 days, because of side effects I couldn't continue. Instead I'm using retin-A cream. It's been a week. It also shows very similar symptoms to accutane. My lips are still very dry and there are cracks. I have hair loss. I made a quick search on the internet, many people say it increases hairloss if used in excess amounts. I don't know what to do. My skin or my hair? KP is 100% an auto-immune or inflammatory disease. The problem is to find what causes inflammation or auto-immune response.
    Levant, how is it going now?
    I would definitely watch reaction closely. one of the quotes in that article is this: "One scientist actually says that vitamin A may not be a great idea for celiac patients, and that even topical ointments containing retinoic acid can potentially enter the bloodstream and cause problems."
    After all, the skin is penetrable, that's why we have nicotine patches and hormone patches and other dermal delivery systems for medicines.
    - bd: 46 yo F; Dr. Woods Black Soap w/Shea Butter for facewash; Sea Salt + Epsom Salt scrub in shower; Cetaphil RestoraDerm unscented lotion, Alba Botanica Kona Coffee After-Sun lotion on face; reg. exercise; OilPulling; a basic multi-vite plus calcium/Vit D, o3s; eating GLUTEN-FREE DIET for Celiac Disease, and not much dairy as I get allergic reaction; Arms 99% clear, face neck chest 98%, legs 90% clear, butt is 99% clear. All dietary treatments above help reduce my sinus congestion and joint pain besides help my skin.

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    Quote Originally Posted by bunnyday View Post
    Levant, how is it going now?
    I would definitely watch reaction closely. one of the quotes in that article is this: "One scientist actually says that vitamin A may not be a great idea for celiac patients, and that even topical ointments containing retinoic acid can potentially enter the bloodstream and cause problems."
    After all, the skin is penetrable, that's why we have nicotine patches and hormone patches and other dermal delivery systems for medicines.
    Retin-A has a little peeling effect, and i think because of this it smoothed my skin and bumps were improved a bit. You're right, tretinoin (retin-a) or isotretinoin (accutane) both have very serious side effects. Retin-A can be used in small areas without too much effect (such as acne on your face, or bumps only on your upper arms) but if you have to apply it on your whole body (like I do), it can enter bloodstream and cause side effects just as accutane does (I think that's what happened to me last time).

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    bumping thread for helenat
    - bd: 46 yo F; Dr. Woods Black Soap w/Shea Butter for facewash; Sea Salt + Epsom Salt scrub in shower; Cetaphil RestoraDerm unscented lotion, Alba Botanica Kona Coffee After-Sun lotion on face; reg. exercise; OilPulling; a basic multi-vite plus calcium/Vit D, o3s; eating GLUTEN-FREE DIET for Celiac Disease, and not much dairy as I get allergic reaction; Arms 99% clear, face neck chest 98%, legs 90% clear, butt is 99% clear. All dietary treatments above help reduce my sinus congestion and joint pain besides help my skin.

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    A guy who understands a lot about natural stuff once looked at my arms when I was grocery shopping and told me my kp had to do with my liver. He said everything about our skin has to do with the liver.

    So I bought this Liver Detox tea from Yogi (I know, HARDLY a medication) AND the Skin Detox tea from the same brand. I TRIED to drink them for 2 days and I have to say, I don't know if it was just luck, but my kp did seemed more behaved and less angry. The teas taste like total ****. I just couldn't stand the taste.

    Since I still have them I'll give them a try again.

    Whoever is out there and wants to give it a try, here is the info. And, again, it doesn't taste good. But tea is cheap and we all love cheap

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    Hi there!!!.. I'm also thinking that your buddy hypotesis could be interesting.. I have been drinking a lot by these days and my KP is like Hell!... Could you please tell me where can I get these Liver Detox Tea?

    Best regards

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    I've had KP for since I was about 13 (I'm 31 now), but it was made much worse by accutane. I've been able to control it with neostrata 15. Over the last few months though I've been getting large itchy bumps mostly on my back and upper back of my arms. Usually I get little if any KP on my back.. generally just little bumps that turn into white heads on my arms. These new ones are very similar to bug bites, because they don't pop or have puss, and don't leave scars. I've had some itchy bumps like this in the past, but they typically stop itching in a half hour or so and go away pretty fast. These ones stay large and itchy for days before finally going away after a few weeks. I'm completely baffled by this and would love any insight someone could provide.

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    dave, My recommendation would be to go to a dermatologist and ask him/her to biopsy the skin immediately adjacent to one of those welts and look for dermatitis herpetiformis which is skin celiac disease (basically.) The lab or the Dr needs to be experienced at looking for it. It's not herpes simplex, the name is similar because the itch and sometimes the blisters are similar. You could also get the bloodtests for celiac disease while you're at it. If you're negative for all that, you could still check out this info: psoriasis,urticaria,andotherskinconditions - jccglutenfree

    keep us posted!
    - bd: 46 yo F; Dr. Woods Black Soap w/Shea Butter for facewash; Sea Salt + Epsom Salt scrub in shower; Cetaphil RestoraDerm unscented lotion, Alba Botanica Kona Coffee After-Sun lotion on face; reg. exercise; OilPulling; a basic multi-vite plus calcium/Vit D, o3s; eating GLUTEN-FREE DIET for Celiac Disease, and not much dairy as I get allergic reaction; Arms 99% clear, face neck chest 98%, legs 90% clear, butt is 99% clear. All dietary treatments above help reduce my sinus congestion and joint pain besides help my skin.

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    Thanks for your reply... I went to the dermatologist today.. since they look just like bug bites and itch he wanted to try a cream on them first before he did a biopsy since it will leave a scar. I told him it was very unlikely they were bug bites since I've been getting them for about 2 months. Also, I wear a suit to work so unless I'm getting bit through my suit it makes no sense. IPlus I live in San Diego were there are very few mosquitos or other bugs for that matter. This is crazy today alone I've gotten about 10 all over my back and arms. This is driving me crazy!

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    dave, you might want to go through the photos linked in this thread: Itchy or Painful KP? Boils or blisters?
    ...see if there's anything you'd like to show your derm. There's a great range of severity and location of DH in those collections. Celiac disease is hugely underdiagnosed in the USA, including dermatitis herpetiformis. The trick with DH is that someone with DH won't necessarily have positive bloodwork for celiac and maybe not even positive results in a small intestine biopsy but that's just a matter of time because DH IS celiac disease and will result in all kinds of damage and increased mortality in the long run.

    It's your description of the "large, itchy bumps" coupled with worsening after accutane treatment that sets off my internal alarm because that's exactly what my DH is like on my back - just discrete itchy, sometimes painful, red lumps that seem like they're going to be deep pimples but never are tho they sometimes get a keratin plug in them, i suspect just from the inflammation. On my tailbone, I get very classic blisters but in other areas, it's more like what you describe. anyway, take a look.
    - bd: 46 yo F; Dr. Woods Black Soap w/Shea Butter for facewash; Sea Salt + Epsom Salt scrub in shower; Cetaphil RestoraDerm unscented lotion, Alba Botanica Kona Coffee After-Sun lotion on face; reg. exercise; OilPulling; a basic multi-vite plus calcium/Vit D, o3s; eating GLUTEN-FREE DIET for Celiac Disease, and not much dairy as I get allergic reaction; Arms 99% clear, face neck chest 98%, legs 90% clear, butt is 99% clear. All dietary treatments above help reduce my sinus congestion and joint pain besides help my skin.

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    Also, note the medical description:
    "pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions."

    pruritic = itchy
    erythematous = reddened
    papular = small, solid, usually inflammatory elevation of the skin that does not contain pus
    vesicular = composed of or relating to small, saclike bodies
    bullous = characterized by blisters or bullae on the skin

    So DH can be any of those last three in appearance: non pus-filled, multiple small pus or fluid filled sacs (herpes-like), or obvious large blisters. At this point, I think derms are still taught that it's very rare and probably only remember that it would be herpes-like because of the name - they don't necessarily recall the other options unless they've had a lot of experience with it, which they don't cause they're not looking for it.
    - bd: 46 yo F; Dr. Woods Black Soap w/Shea Butter for facewash; Sea Salt + Epsom Salt scrub in shower; Cetaphil RestoraDerm unscented lotion, Alba Botanica Kona Coffee After-Sun lotion on face; reg. exercise; OilPulling; a basic multi-vite plus calcium/Vit D, o3s; eating GLUTEN-FREE DIET for Celiac Disease, and not much dairy as I get allergic reaction; Arms 99% clear, face neck chest 98%, legs 90% clear, butt is 99% clear. All dietary treatments above help reduce my sinus congestion and joint pain besides help my skin.

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    Re: Uh-Oh, Retinoic Acid (Retin-A, Accutane) a Culprit in Celiac Disease?

    sorry for my late response.. I thought I had responded earlier, but apparently my message didn't post. So I had my appt with the dermatologist. He gave me an oral steroid and told me I had dermatosis, but acknowledged he didn't know what was causing it. He recommended using non-hyperallegenic products and using a good lotion with alpha hydroxy. He didn't think my diet was causing it because it wasn't bad enough. Apparently if it's not covering your whole body at all times, that's not bad enough for an allergic reaction. He even asked if it was bothering me? As if having red itchy bumps all over me is something I just wanna get used to!

    I think I definitely have what you are describing. It hasn't got any better over the last week or so since my doctors visit. I've also cut way back on my gluten to see if that helped, but haven't seen any results yet. I say cut way back meaning I'm not eating any bread, grains, pasta or oats, but I don't know if some of the stuff has traces or other stuff I'm not familiar with that has gluten. I've been taking fish oil for a month or so, take a multivitamin regularly, and am overall pretty healthy. Although I do generally eat a lot of grains and dairy.I will probably get tested for allergies to gluten and dairy soon. This is getting ridiculous. Thanks for your responses!

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