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Here's Why It MUST NOT Be Genetic!

This is a discussion on Here's Why It MUST NOT Be Genetic! within the General Discussion forums, part of the Keratosis Pilaris Topics category; because of it's importance... Originally Posted by Tatiana_100 ...just because we get kp in certain parts of our body that ...

 
 
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  #46  
Old 09-11-2007, 05:14 PM
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Re: Here's Why It MUST NOT Be Genetic!

because of it's importance...
Quote:
Originally Posted by Tatiana_100 View Post
...just because we get kp in certain parts of our body that that means its not hereditary.
I mean, baldness is hereditary, but a doesnt mean that people are bald all over their bodies...
This is a great example.

Quote:
Originally Posted by diniega View Post
Keratosis Pilaris, like almost any condition, is partially based upon genetics. The propensity to have KP is built into people's genotypes. Whether or not an individual actually physically expresses the disorder (phenotype) is depenedent upon numerous factors, as evidenced by people's testimonies on this forum. Diet, nutrient deficiencies, sunlight exposure, age, and so many other factors will decide whether or not a person with genetic susceptibility to KP actually expresses the condition. I'm not a scientist, but this just seems obvious to me by now based on everything I have read on these forums. If you want proof that KP is linked to our genes, this study lends some convincing evidence.

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
Wow, I'm amazed that you are not a scientist, because you explained this in a very accurate way!
Factors* like the one's you are mentioning are probably the gene activators for this disorder. I'm not saying that the one's that he mentions are the only ones:
*Diet, nutrient deficiencies, sunlight exposure, age, and so many other factors will decide whether or not a person with genetic susceptibility to KP actually expresses the condition.

Quote:
Originally Posted by flushedface View Post
There is no proof that it IS hereditary.
You can visit the website that diniega is posting:http://www.ncbi.nlm.nih.gov/, this website has All the information gathered from the Human Genome Project (ended in 2003) in addition to studies, research and investigations.

Quote:
Originally Posted by allisonsullivan View Post
I read somewhere (not sure where, but I bet you could google it) that KP is linked to a genetic mutation on the 18th chromosome.
A study have linked KP to a anomaly on the 18th chromosome, but this study
was made on just one individual (male) with other disorders.

Quote:
Originally Posted by closetextrovert View Post
A form would require some collaboration...
It would be helpful to have people from the forum suggest questions that would be on the form but they would probably range from personal history, best treatment tried so far, severity of KP etc...
Last, and I could probably do or assist with this part as I worked in a research lab and did data analysis for several years, would be to run stats on the data and see if any trends do appear.
Thank you for your suggestion. We will add a survey form. We will need suggestions for questions we should ask. I have already thought of some.

Quote:
Originally Posted by jax View Post
I think we inherit the tendency for KP, but that it doesn't automatically mean it will express itself. It's only expressed when we provide an environment for it to do so.
Right, but hopefully with the survey we can identify the factors that are causing this gene to express.

Quote:
Originally Posted by Steen View Post
Many (proven) genetic diseases do not manifest themselves until a certain period in the individuals life, and this is because different genes are turned off and on at different stages of your life. You absolutely do not have all of your genes turned on all the time from birth do death! Which genes are expressed depends on environment.
This portion is true. This is the so called "complicated" Gene Expression, you can find info. in different Genetic Books.

Quote:
Originally Posted by cielo View Post
It just leads me to believe that we are the first carriers of it and of course were able to give it to our children. But it probably is genetic and I doubt there will ever be a cure. Only treatment.
Mutations occur every day in our cells and could lead to gene disorders in our progeny (our descendants) or better genes for future generations to adapt to different environments and survive. This is called Species Adaptation.
---------------------------------------------------
With this post I'm trying to clarify certain misconceptions about genetics and KP disorder-with my scientific knowledge.

Some of us doesn't want to believe that this disorder is hereditary and that we could pass it to our children or to our grandchildren.

Thank God that KP is not a lethal genetic disorder. It is only an esthetic issue that sometimes can affect very seriously patients psychologically, but this is why we have this forum, to cheer you up, give you hope when you think you don't have it.

Believe me, some people have found treatments that work for them!!

I welcome any suggestions or comments...

Have a nice day

Note: Sorry about my spelling and grammar errors, my first language is not English.
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  #47  
Old 09-12-2007, 02:17 AM
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Re: Here's Why It MUST NOT Be Genetic!

Quote:
Originally Posted by TheShotOne View Post
Hi Guys!

I'll be as quick as I can on this:

Little introduction, thou:
A few minutes ago I was getting out of the shower and was putting my Clean&Clear astrigent (which someone here recomended and so I use it 3 times a day on my KP areas. I started that, again, 3 days ago), and I was looking at the "rest" of my skin (non-kp skin) and started to think (thinking is always a good thing!): "How the hell I have kp on my legs, buttocks, belly (started a few months ago), on my entire arms and I don't have anywhere else? If it's genetic because my skin can't exfoliate on its own, so how come all the other parts of my body are perfect? And, hummm, I only have kp where my skin is either alligator dry or dry...hummm"

So, yeah, that kept me thinking while I was doing my coffee and I thought I would post this and see if I could start a very nice thread about this issue.

I only have KP where my skin is extremely dry or just dry. Everywhere else I don't even need (or have never even put) moisturizer.

I have, what I should call "invisible kp" on my jaw line, because I can tell the skin has incredibly little bumps, but not red. But that's because I always where SPF on my face and that has a little bit of oil/moisturizer in it (which btw gives me zits!). So I only consider it kp to write in here. I don't even consider kp to myself. I really don't. I have to actually "want" to have kp there to say I have there because it's ridiculously out of sight. No one can see it. BUT my skin in my jaw line IS dry, but I where SPF all the freaking time ( since 17. I'm 24 now), so I guess that's why I "don't have it" there.

I also have dandruff, which I think is the OPPOSITE of kp (it's sheding, when the kp has a "problem" doing it, as doctors say).

I read a thread where everybody said their skin is dry to extremely dry where kp is.

So,( Oh-My-God-Let-Me-Be-Right) it CANNOT be genetic.

It's only where our skin is DRY, that's all! (doesn't this "that's all" sounded soooo nice? )

Guys, I REALLY want to believe in what I'm writing in this thread.

Who can back me up on that? Who here could buy this? Who here think that it does make sense?

I need to be honest with you all: I don't hydrate my dry/kp skin properly or frequently.

You know, it's a drag to moisturize 3 times a day (which is what dermatologist say that's how often dry/extremely dry skin people should moisturize) and the moisturizers are always sticky and it's a lot of effort to take your entire clothe off, put the lotion, spread it evenly, put on your clothes, feel it all sticking to your clothes, or go to sleep and feling it all "grabbing" your bed sheets, etc.

IT'S A DRAG TO MOISTURIZE, MUCH LESS 3 FREAKING TIMES A DAY!!!

I've heard some people here getting kp-free and when I check it, there's ALWAYS a moisturizer in the treatment. All those people that say they got their babies kp-free (because moms usually don't like to put acids on their children, thank god!) by only putting lotions, oils (I'm not mentioning the names of the lotions because that's not what this is about and I would also sound like I'm trying to sell something!), etc etc etc

What about those people?

And, I have to say: When I put Salycilic Acid, I'm actually DRYING my skin (at least as an astrigent, like the one I use).

So, what so you guys have to say about that?

Do you guys think that the trick is to ONLY moisturize (but to the absurdity of 3 times a day), or moisturize and use an AHA cream to speed the exfoliation (to slough away the dead skin cells, although that would be going, I guess, against everything I've just written, but I'll let you guys decide on that ),...

What's your opinion on that?

Let's talk about this a little bit. Ask each other things that could validate this theory and see if this is the deal with kp or if this is NOT the reason for our KP, you know, start a "eliminating" process on possible causes here.

Thank you so much for hearing me out.

I really hope I'm right about this, because, then, it will be a simple solution!!!!!

EDITED: About the redness, if I had to add something about it, I would say it's because we have sensitive skin, and so I think we should use a anti-inflamatory/anti-redness cream, which I WON't say names because I don't want to sound like someone who wants to sell products. But you can check some out at the mag scans I put at another thread.
IT MUST BE GENETIC because i have two sisters and one brother. One of my sisters also has KP: That means 2 out of 4 . At least one of our children will have KP as it is dominant.
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Old 09-12-2007, 07:33 AM
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Re: Here's Why It MUST NOT Be Genetic!

its the genes at some level. Other factors on top of that methinks. Hormones v.important probably. Also diet/allergies. Supplements, good diet, good regime and sunshine should do the trick. In my family lots of red hair (not me ha! escaped!!!) ashma, some eczma. Im so glad I didnt get the other lot. Ashma is no joke having seen it at first hand. Also eczma can be very nasty. Red hair is the worst!!! I will take the kp over the red hair and the others any day!!!!!! Really!!!! ha! .......oh and the freckles aaaaaaaaaaagh no no no.

Last edited by bamber1; 09-12-2007 at 07:34 AM. Reason: forgot to mention
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